Oral hormone substitute therapy, or H.R.T., will increase the chance for doubtlessly deadly blood clots. However a examine in BMJ discovered that hormone substitute delivered by means of the pores and skin by injection or pores and skin patch entails no elevated threat for blood clots.
British researchers checked out 80,396 ladies who had blood clots whereas on varied H.R.T. regimens, evaluating them with 391,494 controls. After adjusting for ethnicity, smoking, alcohol use, continual medical situations and different components, they discovered that oral preparations elevated the general threat of clots by 43 p.c. Oral medication containing equine estrogen greater than doubled the chance in some regimens, though absolutely the threat for blood clots is small.
However pores and skin remedies, together with patches, lotions, gels and under-the-skin injections, had no impact on the chance for blood clots.
About 80 p.c of the ladies within the examine utilizing H.R.T. took the drugs orally, and among the many ladies who used transdermal regimens, 87 p.c used the pores and skin patches.
The lead creator, Dr. Yana Vinogradova, a analysis fellow on the College of Nottingham, stated that she would advise ladies who’re candidates for H.R.T. to start out with the hormonal pores and skin patch. “If that doesn’t help, or if there are skin problems, then the woman should discuss with her doctor what’s next.”